Description
Research areas
Comprehensive study of modern computational and experimental methods for the generation, structure, reactivity and chemical transformations of carbenes, their analogues, free radicals and other related intermediates, as well as unstable molecules with unusual types of chemical bonds, including multiple bonds E = X (E = Si, Ge, Sn; X = C, O, S).
A systematic study of the reactions of diazoalkanes and diazoesters as precursors of carbenes and reagents of 1,3-dipolar cycloaddition to multiple bonds, as well as unusual diazo components in processes similar to azo coupling.
Development of original methods for the synthesis of important organofluorine and other synthons and the organization of the production of compounds with practically useful properties.
Main results
The method of infrared and ultraviolet spectroscopic studies of intermediates and other unstable molecules has been created and successfully applied, with their low-temperature stabilization in inert matrices.
A significant contribution was made to the study of the problem of bicity with the participation of silicon and germanium atoms, in particular, the first experimental observation and study of the double bond Si = C was carried out.
For the first time, systematic studies have been carried out on the role of labile complexes and stages with electron transfer in the reactions of carbene analogs and radicals.
Fundamentally technologically advanced methods for the production of fluoroarenes based on the reactions of [1 + 2] - and [2 + 2] cycloaddition of the available fluorocarbenes, fluoroolefins and fluorodienes to unsaturated compounds have been developed.
The regularities of catalytic cyclopropylation of a wide series of unsaturated compounds by aliphatic diazo compounds have been established, in particular, a technologically advanced method for cyclopropanation of stressed olefins was first developed under conditions of simultaneous generation and catalytic decomposition of diazomethane.
For the first time, the ability of diazocyclopropane and its derivatives to react as a 1,3-dipolar cycloaddition to unsaturated compounds, and in the reaction of azo coupling with aromatic compounds and activated CH-acids. In this case, diazocyclopropane and cyclopropyl diazonium were intercepted under the direct nitrosation of cyclopropylamine by alkyl nitrites.
In collaboration with other organizations, production of a unique hydrocarbon fuel “cyclin” and other high-energy polycyclic hydrocarbons was created; the first domestic production of synthetic pyrethroids was organized; A directed synthesis and study of the properties of new nitrogen-containing polycyclic compounds with various types of biological activity is carried out.
