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Tests to assess the risk of interactions interactions on the panel in vitro tests

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Test panel: stability testing in human liver microsomes, testing the ability to inhibit cytochromes in human liver microsomes (6 CYP450 isoforms), time-dependent inhibition of cytochromes (6 CYP450 isoforms), testing the ability to inhibit the PGP transporter. Analysis Method: HPLC-MS / MS.

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