Testing the metabolic and chemical stability of the compound in the in vitro test panel
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Test panel: test of stability in liver microsomes (2 types) without or with the addition of the S9 fraction, in biological fluids - blood plasma (2 types), artificial gastric and intestinal juice, in buffers with different pH values 2, 4 and 7. Method of analysis : HPLC-MS / MS. See also: