Test metabolism compounds in the panel in vitro ADME tests / Biomedicine / Services

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Test panel: test of stability in liver microsomes (2 types) without or with the addition of the S9 fraction and identification of the metabolizing cytochrome in case of instability, stability of the object in the gastric and intestinal juices, stability in blood plasma (2 types), inhibition of cytochromes in human liver microsomes 6 CYP450 isoforms), plasma protein binding (2 species), blood / plasma distribution, cell permeability and active transport testing on the Caco-2 / PGP model or without PGP, potential cardiotoxicity test (binding to hERG -to nalami heart), prediction of possible metabolic pathways and metabolites using software Light Sight (ABSciex). Analysis Method: HPLC-MS / MS.

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Test metabolism compounds in the panel in vitro ADME tests

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