Description
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Preclinical efficacy studies , including: |
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Investigations of specific activity in vivo on of experimental models and Patolo gi,including: |
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Investigation of the anti-inflammatory activity of the substance on the carrageenin-induced edema model (rats, 3 doses, 1 time point) , GLP |
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Study of the anti-inflammatory activity of a substance on a model of mediator-induced edema (1 test out of the series: histamine-induced edema, serotonin-induced edema, rats, |
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Investigation of the anti-inflammatory activity of a substance in the model of chronic proliferative inflammation "felt granuloma" (rats, 3 doses) , GLP |
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The study of the analgesic activity of the substance in the test "acetic acid cramps" (rodents) |
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The study of the analgesic activity of the substance in the test "hot plate" (rodents) , GLP |
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Study of the ulcerogenic effect of the substance in vivo (1 and 4 times rats) , GLP |
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The study of antihypoxic activity in the normobaric test hypercapnic hypoxia (mice) , GLP |
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A study of antiviral activity in a model vivo (1 test, at least 3 doses, 1 virus subtype / strain, rodents) , GLP |
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Investigation of wound healing properties on the in model vivo , GLP |
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Study of antianemic properties on the model of iron-deficiency anemia , GLP |
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Investigation of specific activity in vitro : |
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Investigation of the anti-inflammatory activity of the substance on the in model vitro (1 test) |
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Cytotoxicity study on the model in vitro (1 test) |
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The study of antitumor activity on the model in vitro (1 test) |
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A study of antiviral activity in a model vitro (1 test) |
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The study of the specific activity of enzymes against substrates in vitro (1 test) |
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Screening producing a recombinant protein for specific activities in relation to substrates s in vitro (1 test , for 1 clone ) |
