Preclinical studies

Preclinical studies security , including:

Acute toxicity study (1 route of administration, 2 genders) , GLP

Comparative Acute Toxicity Study 
2 substances (1 route of administration, 1 floor) , GLP

And a study of acute toxicity (test No. 402, skin application ), GLP OECD

Acute toxicity study (test No. 420 , intragastric administration ), GLP OECD

Acute toxicity study (test No. 42 3 , intragastric administration), GLP OECD

Cumulation Study (1st floor) , GLP

Multiple dose toxicity study (duration of administration - up to 2 weeks ) , GLP

Multiple dose toxicity study ( up to 1 month for administration ) , GLP

Toxicity study with repeated administration (duration of administration - up to 3 months, 1 floor) , GLP

Toxicity study with repeated administration of an object (the duration of administration is up to 
6 months, 1 sex, rats) , GLP

Toxicity study with repeated administration of the object ( test No. 4 07 , 21/28-day intragastric administration ) , GLP OECD

Toxicity study with repeated administration of the object (test No. 410, 21/28-day skin application), GLP OECD

Comparative toxicity study with repeated administration of 2 substances (duration of administration - up to 2 weeks¸1 sex) , GLP

Comparative toxicity study with repeated administration of 2 substances (duration of administration is up to 1 month, 1 gender) , GLP

Research on reproductive (generative) toxicity in males (rats, 48 ​​days old) , GLP

Reproductive toxicity study in females (rats, 15-day administration) , GLP

Reproductive toxicity study (Embree about - and foetotoxic action is logged in the antenatal period of development, the female rats, 19-day administration), GLP

Reproductive toxicity study (Embry about - and foetotoxic effects recorded in the postnatal development of the female rats), GLP

Mutagenicity test ( Ames test ) , GLP

Mutagenicity test ( micronucleus test)

The study of allergenic properties (active skin anaphylaxis, guinea pigs) , GLP

The study of allergenic properties (1 test out of the series: delayed-type hypersensitivity reaction, inflammation response to concanavalin A , mice, 1-fold administration) , GLP

The study of immunotoxicity (effect on humoral immunity in the test for determining the number of antibody-forming cells in the spleen, mouse, 
1-fold introduction) , GLP

The study of immunotoxicity (effect on humoral immunity in the test for determining the number of antibody-forming cells in the spleen, mouse, 
28-day introduction) , GLP

Immunotoxicity study (1 test out of the series: effect on cellular immunity, phagocytosis, 
1-fold introduction) , GLP

The study of the immunogenicity of a biological drug , GLP

And pharmacological safety esearch - the impact of the drug on the vital systems of the body function (1 system from the series: the cardiovascular system, central nervous system, respiratory system and th), GLP